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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HADHA
All Species:
35.76
Human Site:
S257
Identified Species:
71.52
UniProt:
P40939
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40939
NP_000173.2
763
83000
S257
G
L
A
D
K
K
I
S
P
K
R
D
K
G
L
Chimpanzee
Pan troglodytes
XP_515339
763
82965
S257
G
L
A
D
K
K
I
S
P
K
R
D
K
G
L
Rhesus Macaque
Macaca mulatta
XP_001086472
763
83034
S257
G
L
A
D
K
K
I
S
P
K
R
N
K
G
L
Dog
Lupus familis
XP_532894
762
82917
S257
G
L
S
D
K
K
I
S
I
K
R
D
K
G
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8BMS1
763
82651
S257
G
L
A
D
R
K
V
S
A
K
Q
S
K
G
L
Rat
Rattus norvegicus
Q64428
763
82646
S257
G
L
A
D
R
K
V
S
A
K
Q
S
K
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508292
763
82918
S257
D
L
A
D
K
K
V
S
A
K
K
N
K
S
L
Chicken
Gallus gallus
NP_990387
770
83168
S264
G
L
A
N
K
T
V
S
A
K
R
S
K
G
L
Frog
Xenopus laevis
NP_001085618
760
82341
S254
G
I
A
R
K
K
I
S
L
K
K
E
K
G
L
Zebra Danio
Brachydanio rerio
NP_001082906
763
82870
T257
G
L
A
Q
K
K
I
T
L
T
K
E
K
G
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609299
783
84056
V269
L
A
S
G
K
L
R
V
N
R
E
K
S
G
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001192117
703
75892
K261
D
L
A
A
G
N
I
K
T
D
K
P
K
T
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
98.1
89.6
N.A.
86.5
85.1
N.A.
85.5
77.2
77.4
72.3
N.A.
54.6
N.A.
N.A.
59.5
Protein Similarity:
100
99.8
99.3
95.1
N.A.
94
93.5
N.A.
92.4
87.9
89.2
84.8
N.A.
71.3
N.A.
N.A.
72.4
P-Site Identity:
100
100
93.3
86.6
N.A.
66.6
66.6
N.A.
60
66.6
66.6
53.3
N.A.
20
N.A.
N.A.
26.6
P-Site Similarity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
80
80
86.6
73.3
N.A.
33.3
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
84
9
0
0
0
0
34
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
17
0
0
59
0
0
0
0
0
9
0
25
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
9
17
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
75
0
0
9
9
0
0
0
0
0
0
0
0
84
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
9
0
0
0
0
59
0
9
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
75
75
0
9
0
75
34
9
92
0
0
% K
% Leu:
9
84
0
0
0
9
0
0
17
0
0
0
0
0
84
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% M
% Asn:
0
0
0
9
0
9
0
0
9
0
0
17
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
25
0
0
9
0
0
0
% P
% Gln:
0
0
0
9
0
0
0
0
0
0
17
0
0
0
0
% Q
% Arg:
0
0
0
9
17
0
9
0
0
9
42
0
0
0
0
% R
% Ser:
0
0
17
0
0
0
0
75
0
0
0
25
9
9
0
% S
% Thr:
0
0
0
0
0
9
0
9
9
9
0
0
0
9
0
% T
% Val:
0
0
0
0
0
0
34
9
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _